19-nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, and the intermediates of this process, their use as medicaments and compositions
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United States of America Patent
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Aug 28, 2001
Grant Date -
N/A
app pub date -
Jun 9, 1994
filing date -
Dec 20, 1991
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of formula (I), wherein R.sub.17 and R'.sub.17 are such that: either R.sub.17 and R'.sub.17 together form ketone, hydrazono, oxime or methylene, or R.sub.17 is hydroxyl, hydroxymethyl or acyloxy and R'.sub.17 is hydrogen, alkyl or optionally substitued alkenyl or alkynyl; R.sub.3 is hydrogen or alkyl; R.sub.16 is hydrogen, halogen or alkyl; m is 0, 1 or 2; X, Y and Z are such that: X is methylene, arylene or arylenoxy bonded to the steroid by a carbon atom; Y is a saturated or unsaturated straight or branched aliphatic chain which is optionally interrupted by oxygen; and Z is aryl, arylalkyl or straight or branched alkyl; addition salts thereof, a preparation method therefor, medicinal uses thereof, compositions containing said compounds, and resulting novel intermediates. ##STR1##
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