System for using ligands in particle separation
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United States of America Patent
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Aug 28, 2001
Issued Date -
N/A
app pub date -
May 16, 2000
filing date -
Feb 22, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
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