Chemical compounds
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United States of America Patent
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Aug 21, 2001
Issued Date -
N/A
app pub date -
May 19, 1999
filing date -
Jul 23, 1992
priority date (Note) -
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Abstract
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.
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