Pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds
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United States of America Patent
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Aug 14, 2001
Grant Date -
N/A
app pub date -
Dec 21, 1998
filing date -
Apr 18, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The subject of the invention is the products of formula (I): ##STR1## in which either R.sub.1 represents halogen, hydroxyl, (C.sub.1 -C.sub.8) alkyloxy or (C.sub.1 -C.sub.12) acyloxy, and R.sub.2 represents halogen or hydrogen, or R.sub.1 and R.sub.2 form together a double bond, Z is chosen from optionally substituted (C.sub.1 -C.sub.8) alkylthio, optionally substituted arylthio, (C.sub.1 -C.sub.8) alkyloxy, halogen, cyano, mercapto, thiocyanato and (CH.sub.2).sub.0-1 --CO.sub.2 H, optionally esterified, Y represents hydrogen or methyl, the dotted line in position 1-2 or 5-6 optionally representing a second bond, as well as their addition salts, their preparation process, the intermediates of this process and the pharmaceutical compositions containing them.
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