Modified factor VIII cDNA
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United States of America Patent
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Aug 7, 2001
Grant Date -
N/A
app pub date -
Mar 16, 2000
filing date -
Mar 17, 1999
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Abstract
A modified Factor VIII cDNA is described comprising deletion of the B-domain and insertion of at least one truncated Factor IX intron 1 in the Factor VIII cDNA. The modified Factor VIII cDNA may be used for the production of a high yield of Factor VIII in vitro. The modified Factor VIII cDNA may be incorporated into a vector for gene therapy.
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