Peptide antagonists of DP transcription factors
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United States of America Patent
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Jul 31, 2001
Grant Date -
N/A
app pub date -
May 27, 1999
filing date -
Dec 20, 1996
priority date (Note) -
Expired
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Abstract
The invention provides a polypeptide consisting essentially of a sequence corresponding to residues 163 to 199 of DP-1 as shown in the Figure, and fragments and variants thereof capable of antagonising the heterodimerization of a DP protein with an E2F protein. Such peptides may be used to induce apoptosis in a cell by introducing into the cell an effective amount of said peptide. Such cells include cardiovascular cells, and the peptide may be delivered in a stent to treat or prevent restinosis.
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