Screening test for the lethal genetic trait of recurrent spontaneous pregnancy loss
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United States of America Patent
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Jul 31, 2001
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N/A
app pub date -
Sep 22, 1999
filing date -
Sep 22, 1999
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Expired
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Abstract
A screening test to identify women carrying a lethal genetic trait that predisposes to recurrent spontaneous pregnancy loss. The test method involves the quantitative determination of the frequency of highly skewed X chromosome inactivation in DNA derived from tissue cells of female patients, relative to appropriate normal control women. 'Highly skewed' is defined as preferential use of one chromosome in at least 90% of the patient's cells being tested. Suitable test tissues include, but are not limited to, peripheral leukocytes, oral mucosal cells, and biopsy material.
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