Nucleic acid constructs whose activity is affected by inhibitors of cyclin-dependent kinases and uses thereof
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United States of America Patent
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Jul 24, 2001
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N/A
app pub date -
Dec 18, 1998
filing date -
Dec 20, 1997
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Expired
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Abstract
The present application discloses nucleic acid constructs comprising nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, fragments and variants thereof, some of which possess a dominant interfering character.
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