Use of 2-phenylmorpholin-5-one derivatives

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United States of America Patent

PATENT NO 6265402
SERIAL NO

09242818

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A 2-phenylmorpholin-5-one derivative having the formula (I): ##STR1## wherein R.sub.1 represents a C.sub.1 to C.sub.8 alkyl group, a C.sub.3 to C.sub.7 cycloalkyl group or an indanyl group, R.sub.2 represents a C.sub.1 to C.sub.4 alkyl group, R.sub.3 represents a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, etc., R.sub.4 represents a hydrogen atom, a C.sub.1 to C.sub.6 alkyl group, etc., R.sub.5, R.sub.6 represent a hydrogen atom, a C.sub.1 to C.sub.5 alkyl group, etc., an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same. The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.

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Patent Owner(s)

Patent OwnerAddress
NIKKEN CHEMICALS CO LTD4-14 TSUKIJI 5-CHOME CHUO-KU TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ina, Shinji Omiya, JP 10 58
Noda, Kyoji Omiya, JP 7 183
Yamana, Kenjirou Omiya, JP 6 45

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