PCR amplification of rearranged genomic variable regions of immunoglobulin genes

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United States of America Patent

PATENT NO 6258529
SERIAL NO

08348548

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Abstract

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The invention features methods for isolating immunoglobulin variable region genes, and the use of these genes in the production of chimeric and isotype switched antibodies. The invention also features substantially pure DNA encoding a variable region of the antibody produced by hybridoma cell line HNK-20, and chimeric antibodies containing this variable region.

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Patent Owner(s)

Patent OwnerAddress
ACAMBIS INC38 SIDNEY STREET CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berdoz, Jose La Tour-de-Peilz, CH 1 5
Kraehenbuhl, Jean-Pierre Rivaz, CH 11 107

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