Antiviral liponucleosides: treatment of hepatitis B
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United States of America Patent
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Jun 26, 2001
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N/A
app pub date -
Apr 4, 1994
filing date -
Jul 7, 1988
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Expired
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Abstract
Compounds for treating hepatitis B infections. The compounds consist of nucleoside analogues having anti-hepatitis B activity which are linked, commonly through a 5' phosphate of the pentose residue, to one of a selected group of lipids. The lipophilic nature of these compounds provides an advantage over the use of the nucleoside analogue alone, making it possible to incorporate them into the lamellar structure of liposomes, either alone or in combination with similar lipid molecules. In the form of appropriately sized liposomes, these anti-hepatitis B agents are preferentially taken up by the liver cells which have been found to harbor the target virus.
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