6-phenyltetrahydro-1,3-oxazin-2-one derivative and pharmaceutical composition containing the same
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United States of America Patent
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Jun 26, 2001
Grant Date -
N/A
app pub date -
Feb 1, 1999
filing date -
Jul 31, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A 6-phenyltetrahydro-1,3-oxazin-2-one derivative having the formula (I): ##STR1## wherein, R.sub.1 is an unsubstituted or substituted C.sub.1 to C.sub.8 alkyl group; an unsubstituted or substituted C.sub.3 to C.sub.7 cycloalkyl group;, etc., R.sub.2 is a C.sub.1 to C.sub.4 alkyl group, R.sub.3 is H; an unsubstituted or substituted C.sub.1 to C.sub.5 alkyl group; etc., R.sub.4 is H; an unsubstituted or substituted C.sub.1 to C.sub.6 alkyl group, and R.sub.5 and R.sub.6 are independently a hydrogen atom; an unsubstituted or substituted C.sub.1 to C.sub.5 alkyl group; etc. an optical isomer thereof, or a pharmacologically acceptable salt thereof, or a hydrate or a solvate thereof and pharmaceutical compositions containing the same, in particular a drug for the prevention or treatment of inflammatory diseases and a drug for asthma. The above 6-phenyltetrahydro-1,3-oxazin-2-one derivative has a strong type IV PDE inhibitory activity and has a bronchiodilator and antiinflammatory effects.
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