Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
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United States of America Patent
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Jun 26, 2001
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N/A
app pub date -
Aug 25, 1998
filing date -
Feb 6, 1996
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Expired
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Abstract
A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
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