Phase modulation spectroscopy
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United States of America Patent
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Jun 12, 2001
Grant Date -
N/A
app pub date -
Feb 13, 1997
filing date -
Jan 24, 1991
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Abstract
A spectroscopic system for quantifying in vivo concentration of an absorptive pigment in biological tissue includes an oscillator for generating a first carrier waveform of a first frequency on the order of 10.sup.8 Hz, a light source for generating light of at least two selected wavelengths modulated by the carrier waveform, and a detector for detecting radiation that has migrated over photon migration paths in the tissue from an input port to a detection port spaced several centimeters apart. At least one of the wavelengths is sensitive to concentration of an absorptive pigment present in the tissue, while the tissue exhibits similar scattering properties at the two wavelengths. A phase detector compares, at each wavelength, the detected radiation with the introduced radiation and determines therefrom the phase shift of the detected radiation at each wavelength. A processor quantifies the concentration of the absorptive pigment by employing the phase shifts measured at the two wavelengths and also employing a scattering property of the tissue.
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