Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease

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United States of America Patent

PATENT NO 6245736
SERIAL NO

08949496

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Abstract

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The invention relates to the use of bradykinin antagonists for the production of pharmaceuticals for the treatment and prevention of Alzheimer's disease. Suitable bradykinin antagonists are peptides which inhibit the effects of the Alzheimer's protein amyloid (.beta./A4) on isolated endothelial cells. A particularly suitable peptide is H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH (HOE 140) and its physiologically tolerable salts.

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Patent Owner(s)

Patent OwnerAddress
HOECHST MARION ROUSSEL DEUTSCHLAND GMBHINDUSTRIEPARK HOECHST D-65926 FRANKFURT AM MAIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Breipohl, Gerhard Frankfurt, DE 46 380
Heitsch, Holger Mainz-Kastel, DE 37 267
Henke, Stephan Hofheim, DE 26 117
Knolle, Jochen Kriftel, DE 68 504
Wiemer, Gabriele Kronberg, DE 9 76
Wirth, Klaus Kriftel, DE 83 461

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