Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same
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United States of America Patent
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Jun 12, 2001
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N/A
app pub date -
Dec 13, 1999
filing date -
Jun 13, 1997
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Abstract
As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I) ##STR1## wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.
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