Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
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United States of America Patent
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Jun 12, 2001
Grant Date -
N/A
app pub date -
Dec 28, 1992
filing date -
Jan 7, 1992
priority date (Note) -
Expired
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Abstract
A lyophilized composition comprising (a) a conjugate comprising a N-alkyl methacrylamide-based copolymer and an anthracycline glycoside linked through a peptide spacer to the copolymer and (b) a cosolubilizing agent may optionally also contain (c) a filler. Also optionally, a targeting moiety may be linked to the copolymer of the conjugate via a peptide spacer. An injectable solution of the conjugate is obtained by reconstitution of the lyophilized composition.
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