Self-assembled metal colloid monolayers having size and density gradients
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United States of America Patent
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Jun 5, 2001
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N/A
app pub date -
Jan 12, 2000
filing date -
Sep 4, 1996
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Abstract
A biosensor based on complexes between biomolecule receptors and colloidal Au nanoparticles, and more specifically, colloid layers of receptor/Au complexes that can be used to detect biomolecule analytes through measuring of binding-induced changes in electrical resistance or surface plasmon resonance. Also disclosed is a method for detecting and analysing carrier-borne chemical compounds with Raman spectroscopy using an improved SERS substrate. Further disclosed is an improved method for detecting compounds in solvents using capillary electrophoresis in conjunction with Raman spectroscopy.
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