Diagnostic application of sono-chemical excitation of fluorescent photosensitizers
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United States of America Patent
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May 15, 2001
Grant Date -
N/A
app pub date -
Oct 5, 1998
filing date -
Oct 9, 1997
priority date (Note) -
Expired
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Abstract
Disclosed is a method for generating an image of a selected area of tissue, the method includes steps of: (a) providing a fluorescent photosensitizer compound in combination with a hydrogen-containing solvent to the selected area of tissue; (b) generating acoustic energy for generating free radicals from the solvent; (c) reacting the free radicals with an oxalate ester to generate a key intermediate; (d) transferring chemical energy to the fluorescent photosensitizer compound from the key intermediate; (e) activating the fluorescent photosensitizer compound with the transferred energy to emit long wavelength light; and (f) detecting the long wavelength light to generate the image of the selected area of tissue. In one embodiment the oxalate ester is comprised of ester bis (2,4-dinitrophenyl) oxalate (DNPO). In one application, a selected area of living tissue is analyzed to identify an abnormality within the tissue.
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