Composition for controlled and sustained transdermal administration
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United States of America Patent
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May 15, 2001
Grant Date -
N/A
app pub date -
Sep 15, 1998
filing date -
Sep 17, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A patch for transdermal administration of drugs through controlled release system, consisting essentially of: A) a flexible backing layer; B) an adhesive layer comprising: an adhesive pressure sensitive adhesive polymeric matrix, a cohesion improver, a tackifier agent, a combination of permeation enhancers consisting of a first component which is a saturated fatty acid or fatty alcohol represented by the formula CH.sub.3 --(CH.sub.2).sub.n --COOH or CH.sub.3 --(CH2).sub.n --CH.sub.2 OH respectively, in which n is an integer from 6 to 16, and of a second component which is a monounsaturated fatty acid or fatty alcohol represented by the formula CH.sub.3 --(C.sub.n H.sub.2(n-1))--COOH or CH.sub.3 --(C.sub.n H.sub.2(n-1))--CH.sub.2 OH respectively, in which n is an integer from 8 to 22, with the provision that the chain lenght of the first component is different from that of the second component, C) a protective liner, which is removed at the moment of use.
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