Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same
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United States of America Patent
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May 8, 2001
Grant Date -
N/A
app pub date -
Jan 19, 2000
filing date -
Sep 28, 1999
priority date (Note) -
Expired
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Abstract
The present invention provides pharmaceutical formulations which contain (a) an inert core of sugar, sugar and starch, or microcrystalline cellulose, (b) a drug emulsion layer which is made from mixing a free base of benzimidazole derivative (such as omeprazole or lansoprazole) with a nonionic surfactant and water, (c) a protective coating which is made of a film-forming compound, and optionally a plasticizer or excipient, and (d) an enteric coating which is made of a pharmaceutically acceptable polymer and a plasticizer. Optionally, a basic amino acid can be added to the drug emulsion layer or the protective coating. The present invention also provides the method for making the pharmaceutical formulations.
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