Synthesis of new .beta.-lactams
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United States of America Patent
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May 1, 2001
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N/A
app pub date -
Dec 15, 1998
filing date -
Dec 22, 1997
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Expired
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Abstract
The object of the present invention is the development of new chiral auxiliaries for improved .beta.-lactam formation that control both the diastereoselectivity of .beta.-lactam formation and which can be removed without destruction of the sensitive azetidinone ring, providing valuable intermediates for coupling to the C-13 hydroxyl group of anti-tumor taxanes, such as paclitaxel. Further, the object of the present invention is enantiomerically pure (S)-(-)-1-(p-methoxy-phenyl)propyl-1-amine.
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