Solid phases for target nucleic acid detection, process for production thereof, and method of target nucleic acid detection
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United States of America Patent
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May 1, 2001
Grant Date -
N/A
app pub date -
Apr 27, 1998
filing date -
Sep 13, 1996
priority date (Note) -
Expired
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Abstract
A solid phase comprising at least one pair of probes which are capable of sequentially hybridizing with a particular target nucleic acid sequence is provided. The probe pair(s) are immobilized on the solid phase through a linker portion wherein they occupy a restricted spatial arrangement such that they can be ligated by an enzyme when the they sequentially hybridize to a selected target sequence. In addition a method wherein the solid phase is utilized to detection a target nucleic acid is disclosed.
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