Anthranilic acid derivatives as multi drug resistance modulators
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United States of America Patent
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Apr 17, 2001
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N/A
app pub date -
Jun 9, 1999
filing date -
Oct 18, 1996
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Abstract
Anthranilic acids of formula (I): ##STR1## wherein each of R to R.sup.9 is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, --S--(CH.sub.2).sub.p or --O--(CHO.sub.2).sub.p -- wherein p is from 1 to 6 and Ar is an unsaturated carbocyclic or heterocyclic group, and the pharmaceutically acceptable salts thereof, have activity as inhibitors of P-glycoprotein and may thus be used, inter alia, as modulators of multidrug resistance in the treatment of multidrug resistant cancers, for example to potentiate the cytotoxicity of a cancer drug.
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