Fluorinated neurokinin A antagonists

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United States of America Patent

PATENT NO 6218364
SERIAL NO

08638407

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Abstract

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Peptide derivatives which are antagonists of neurokinin A. The derivatives have a modified peptide bond having a reduced amide and a fluorinated alkyl attached to the nitrogen atom of the modified peptide bond. For example, Asp-Ser-Phe-Val-Gly-Leu.PSI.[CH.sub.2 N(CH.sub.2 CF.sub.3)]Leu(NH.sub.2).

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Patent Owner(s)

Patent OwnerAddress
MERRELL PHARMACEUTICALS INC2110 EAST GALBRAITH ROAD CINCINNATI OH 45215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Harbeson, Scott L 1000 Windsor St., Cincinnati, OH 45206 94 1201
McCarthy, James R 6448 Foxview Pl., West Chester, OH 45069 77 342

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