Site-specific conjugation of glycoproteins

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6218160
SERIAL NO

09175785

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention describes a site specific conjugation method for glycoproteins wherein a stable dihydrazone bond is formed between the glycoproteins and the glycoproteins retain full activity. Also described is a novel glycoprotein-glycoprotein conjugate of the formula ##STR1## wherein X and Y are glycoproteins modified such that the vicinal hydroxyl groups of the carbohydrate moieties in the glycoproteins have been oxidized to aldehydes which are then reacted with a hydrazide functional group to form a hydrazone bond which is represented in Formula I by '--C.dbd.NNH--'.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
ROCHE DIAGNOSTICS CORPORATION9115 HAGUE ROAD P O BOX 50528 INDIANAPOLIS IN 46250

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Duan, Chuanming Larry Hockessin, DE 1 11

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation