Site-specific conjugation of glycoproteins
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United States of America Patent
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Apr 17, 2001
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N/A
app pub date -
Oct 20, 1998
filing date -
Oct 31, 1997
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Expired
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Abstract
The present invention describes a site specific conjugation method for glycoproteins wherein a stable dihydrazone bond is formed between the glycoproteins and the glycoproteins retain full activity. Also described is a novel glycoprotein-glycoprotein conjugate of the formula ##STR1## wherein X and Y are glycoproteins modified such that the vicinal hydroxyl groups of the carbohydrate moieties in the glycoproteins have been oxidized to aldehydes which are then reacted with a hydrazide functional group to form a hydrazone bond which is represented in Formula I by '--C.dbd.NNH--'.
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