Allosteric inhibitors of pyruvate kinase
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United States of America Patent
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Apr 10, 2001
Grant Date -
N/A
app pub date -
Mar 24, 1998
filing date -
Mar 24, 1998
priority date (Note) -
Expired
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Abstract
Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate.
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