Substituted phenyl compounds
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Apr 3, 2001
Grant Date -
N/A
app pub date -
Jun 27, 1997
filing date -
Nov 12, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of formula (I) are described wherein R.sup.1 is hydrogen, -(lower alkyl).sub.q (CO.sub.2 R.sup.6 or OH), --CN, --C(R.sup.7).dbd.NOR.sup.8, NO.sub.2, --O(lower alkyl)R.sup.9, --C.tbd.C--R.sup.10, --CR.sup.11.dbd.C(R.sup.12)(R.sup.13), --C(.dbd.O)CH.sub.2 C(.dbd.O)CO.sub.2 H, --CO(R.sup.14), alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, thiocarbamoyl, substituted carbamoyl, substituted thiocarbamoyl, sulphamoyl or an optionally substituted nitrogen-containing ring, m, n, o and p are independently zero or 1 and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are various groups; and physiologically acceptable salts, N-oxides and prodrugs thereof. The compounds have endothelin antagonist activity and are useful as pharmaceuticals.
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