Cationic virosomes as transfer system for genetic material
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United States of America Patent
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Apr 3, 2001
Grant Date -
N/A
app pub date -
Oct 8, 1999
filing date -
May 8, 1996
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Expired
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Abstract
The present invention relates to a positively charged virosome for efficient delivery of genetic material to resting or proliferating mammalian cells in vitro and in vivo. The virosome membrane contains cationic and/or polycationic lipids, at least one viral fusion peptide and preferably at least one cell-specific marker, advantageously selected from the group consisting of monoclonal antibodies, antibody fragments F(ab').sub.2 and Fab', cytokines, and growth factors, for a selective detection and binding of target cells. The invention further relates to a method for the manufacture of the novel virosomes and to applications thereof, particularly for the manufacture of pharmaceutical compositions to treat cancer or leukemia.
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