Process for the preparation of arylmetal compounds and their reaction with electrophilic reagents
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United States of America Patent
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Mar 27, 2001
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N/A
app pub date -
Dec 17, 1999
filing date -
Dec 19, 1998
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Abstract
Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.
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