Bis-phosphonate confugates with alkylating moieties having antitumor activity
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United States of America Patent
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Mar 27, 2001
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N/A
app pub date -
Jan 13, 2000
filing date -
Mar 27, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
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