Magnetically responsive compositions for carrying biologically active substances and methods of production and use
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United States of America Patent
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Mar 13, 2001
Grant Date -
N/A
app pub date -
Jan 6, 1998
filing date -
Jan 26, 1994
priority date (Note) -
Expired
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Abstract
A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0.2 to 5.0 .mu.m in size, and preferably between 0.5 and 5.0 .mu.m, containing 1.0 to 95.0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc.sup.99, and antisense-C Myc oligonucleotide, an hematoporphyrin derivative, 6-mercaptopurine, Amphotericin B, and Camptothecin have been produced using this invention. Magnetic carrier particles having diagnostic quantities of adsorbed Re.sup.186 and Re.sup.188 have also been produced using this invention.
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