Antibody conjugates

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United States of America Patent

PATENT NO 6197299
SERIAL NO

09154310

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.

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Patent Owner(s)

Patent OwnerAddress
ACTIVE BIOTECH AB223 63 LUND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ANGkerblom, Eva Uppsala, SE 2 23
Dohlsten, Mikael Lund, SE 10 253
Hedlund, Gunnar Lund, SE 25 583
Kalland, Terje Loddekopinge, SE 12 319
Lando, Peter A Malmo, SE 2 29

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