Agents for promoting bone formation
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United States of America Patent
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Feb 27, 2001
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N/A
app pub date -
Apr 20, 1999
filing date -
Dec 8, 1995
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Abstract
The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by the following general formula (IX) and so on, as well as a biologically acceptable salt thereof ##STR1## wherein R.sub.16 represents --N(R.sub.20).sub.2 (R.sub.20 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group), R.sub.17 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.18 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group and so on, R.sub.19 represents OH, NH.sub.2 and so on, Y represents --NH--, --O-- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
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