Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof
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United States of America Patent
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Feb 27, 2001
Grant Date -
N/A
app pub date -
Mar 4, 1999
filing date -
May 23, 1996
priority date (Note) -
Expired
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Abstract
This invention relates to locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof, which can show continuous drug effect for a long time by controlling the release time and by making the drug remain in the periodontal pocket for a prolonged time. The composition is prepared by i) making a microsphere containing the physiologically active substance, ii) making the mixture of the microspheres and water-soluble polymer such as polysaccharides iii) making the mixture into the form of film or strip or/and iv) coating the film or strip with a cation aqueous solution such as calcium and barium. The present pharmaceutical composition can be easily administered using forceps, has minimized side effects and maximizes the effect by releasing the active substance at the minimum dose, and make the patients feel comfortable.
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