Method to detect CMV by hybridization with a gp55 specific DNA probe
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United States of America Patent
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Feb 20, 2001
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app pub date -
May 24, 1995
filing date -
Jan 29, 1988
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Abstract
The present invention provides recombinant polypeptides derived from CMV glycoprotein gB and truncated fragments thereof which contain at least one epitope which is immunologically identifiable with one encoded by the CMV genome. The complete characterization of the gB protein, including the identity of glycoprotein gp55, permits the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. This invention provides recombinant polypeptides and recombinant polynucleotides encoding these polypeptides wherein a neutralizing epitope of gB is localized within gp55.
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