Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa
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United States of America Patent
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Feb 20, 2001
Grant Date -
N/A
app pub date -
May 8, 1998
filing date -
May 8, 1998
priority date (Note) -
Expired
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Abstract
The present invention describes a surprising new and effective pharmaceutical composition comprising microparticles and a pharmaceutically acceptable carrier. In particular, the present invention describes a pharmaceutical composition containing microparticles off a matrix material into which is infused a therapeutic agent. The present invention further provides a method of infusing a therapeutic agent such as a protein or peptide into a matrix material to form microparticles containing said therapeutic agent by employing a compressed solvent which is normally gaseous at ambient temperature and pressure. A method is also disclosed of treating or preventing a disease in a mammal by administering to said mammal through a mucosal membrane an effective amount of a pharmaceutical composition comprising microparticles containing a therapeutic agent which effectively treats the disease or disorder.
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