Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds

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United States of America Patent

PATENT NO 6187817
SERIAL NO

08942845

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Abstract

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Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent. Combinations of these time periods can also be employed.

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Patent Owner(s)

Patent OwnerAddress
SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINEP O BOX 19230 SPRINGFIELD IL 62794

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campbell, Kathleen C M Glenarm, IL 4 35

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