Anti-viral guanosine-rich oligonucleotides
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United States of America Patent
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Feb 6, 2001
Grant Date -
N/A
app pub date -
Oct 23, 1995
filing date -
Apr 23, 1993
priority date (Note) -
Expired
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Abstract
The oligonucleotides have sufficient guanosine to form a guanosine tetrad and can be composed of at least about 40% guanosine nucleotides, the nucleotide sequence containing at least two runs of at least two guanosines. Some of the new oligonucleotides also contain phosphorothioate backbones and 3' end modifications. Representative guanosine-rich oligonucleotides of the present invention demonstrate anti-viral activity in tissue culture against HSV-2, HIV-1, HCMV and FMLV, and show specific inhibition of bacterial RNA polymerase enzymes T7 and T3, the FMLV and HIV-1 reverse transcriptase enzyme and eukaryotic RNA polymerase.
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