Anthracycline derivatives having 4-amino-2,4,6-trideoxy-2 fluoro-.alpha.-L-talopyranosyl group
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United States of America Patent
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Feb 6, 2001
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N/A
app pub date -
Dec 16, 1997
filing date -
Dec 16, 1996
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Expired
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Abstract
7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-.alpha.-L-talopyranosyl)-daunomycinone or -adriamycinone is now synthesized as a novel daunomycinone or adriamycinone derivative having the general formula ##STR1## wherein R is a hydrogen atom or hydroxyl group. These novel compounds according to this invention exhibit excellent antitumor activities and have a high solubility in water, and hence they are useful as an antitumor agent.
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