Membrane formed by an acrylonitrile-based polymer
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United States of America Patent
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Jan 30, 2001
Grant Date -
N/A
app pub date -
Jan 31, 1998
filing date -
Apr 27, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer containing --CH.sub.2 --CH(--C.tbd.N)-- units, and grafting polyalkylene oxide polymer chains to the backbone polymer through the reactive sites. Either the backbone polymer of a polymer resin or a permselective polymer membrane can be grafted. When a resin is used, it is formed into a permselective polymer membrane using known methods. The resulting permselective membrane can be formed into hollow fibers or flat sheets for the encapsulation of living cells. The encapsulated cells are then implanted into a patient in need of the biologically active factors produced by the cells. The permselective graft polymer membrane exhibits good molecular diffusion with minimal protein adsorption.
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