Pharmaceutical compositions and method for prophylaxis and therapy of radical-mediated cell damage
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United States of America Patent
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Jan 9, 2001
Grant Date -
N/A
app pub date -
May 9, 1996
filing date -
Nov 10, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being. The at least one steroid is selected from the group consisting of ent-estradiol, 17.alpha.-estradiol, 8-dehydro-estradiol, 8-dehydro-17.alpha.-estradiol, 8(14)-dehydroestradiol, 6,8-didehydro-17.alpha.-estradiol, 6-dehydroestriol, 9(11)-dehydroestriol, 20-hydroxymethyl-3-hydroxy-19-norpregna-1,3,5(10)-triene, 14.alpha., 15.alpha.-methylene-8-dehydroestradiol, 14.alpha., 15.alpha.-methylene-estradiol, 2-hydroxy-estradiol-3-methyl ether, 3-hydroxy-1,3,5(10)-estratriene-17S-spirooxirane, 3-hydroxy-1,3,5(10),9(11)-estratetraene-17S-spirooxirane, and 14.beta.,15.beta.-methylene-8-dehydroestradiol. This method strongly inhibits changes in cells and tissues, such as lipid peroxidation and oxidation of low-density lipoprotein (LDL) cholesterol, triggered by reaction oxygen species, free oxygen radicals and other forms of radicals and thus reduces attendant irreversible membrane and endothelial damage.
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