Serine protease inhibitors comprising .alpha.-keto heterocycles
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United States of America Patent
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Dec 12, 2000
Issued Date -
N/A
app pub date -
May 20, 1997
filing date -
Nov 21, 1994
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Expired
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Abstract
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also provided are methods for detecting or quantifying the activity of a serine protease in a pure sample.
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