Racemization of precursors to levobupivacaine and analogues thereof
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United States of America Patent
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Dec 5, 2000
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N/A
app pub date -
Feb 12, 1999
filing date -
Oct 7, 1994
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Abstract
A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture of a mixture enriched in the opposite enantiomer from that desired, with the optically-active acid in a solvent comprising an acid that causes racemisation, in the absence of aldehyde.
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