Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
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United States of America Patent
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Nov 28, 2000
Grant Date -
N/A
app pub date -
Jan 22, 1999
filing date -
Jan 22, 1999
priority date (Note) -
Expired
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Abstract
A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structure by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca.sup.2+ or Zn.sup.2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing pharmaceutical agents or biologically relevant molecules. Small-sized cochleates may be administered orally or through the mucosa to obtain an effective method of treatment.
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