Serine protease inhibitors-tripeptoid analogs

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United States of America Patent

PATENT NO 6150334
SERIAL NO

08985201

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Abstract

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The present invention relates to certain compounds comprising substituted oxadiazole, thiadiazole and triazole structures which are useful as inhibitors of serine proteases, including human neutrophil elastase (HNE). Compounds described herein are characterized by their relatively low molecular weight, high potency and selectivity with respect to HNE, and can be used to effectively prevent, alleviate or otherwise treat disease states characterized by the degradation of connective tissue by proteases in humans.

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Patent Owner(s)

Patent OwnerAddress
CORTECH INC376 MAIN STREET BEDMINSTER NJ 07921

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gyorkos, Albert C Westminster, CO 8 178
Spruce, Lyle W Chula Vista, CA 40 602

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