Nuclear factors associated with transcriptional regulation
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United States of America Patent
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Nov 21, 2000
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Jan 9, 1986
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Expired
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Abstract
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
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