Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
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United States of America Patent
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Nov 14, 2000
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Dec 29, 1998
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Dec 29, 1998
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Abstract
Disclosed and claimed are a method for the purification of polysaccharide-protein conjugate vaccines by ultrafiltration in a saturated solution of ammonium sulfate. The ultrafiltration method of the present invention provides an efficient, readily scalable method for removal of unbound polysaccharides from polysaccharide-protein vaccines, thereby improving the purity and consistency of the polysaccharide-protein vaccines.
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