Process for the preparation of 4-(des-dimethylamino)-tetracyclines
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United States of America Patent
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Nov 7, 2000
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N/A
app pub date -
May 24, 1999
filing date -
May 26, 1998
priority date (Note) -
Expired
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Abstract
The present invention refers to a process for the preparation of 4-(des-dimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(des-dimethylamino)-tetracyclines are isolated by extraction with an organic solvent.
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