N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides

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United States of America Patent

PATENT NO 6127357
SERIAL NO

08438812

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Abstract

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Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents, particularly 5-HT.sub.1A antagonists and may be used, for example, as anxiolytics. In the formula A is C.sub.2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R.sup.1 is a mono or bicyclic aryl or heteroaryl radical, R.sup.2 is a mono or bicyclic heteroaryl radical and R.sup.3 is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.

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Patent Owner(s)

Patent OwnerAddress
JOHN WYETH & BROTHER LTDBURKE COUNTY ENGLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cliffe, Ian Anthony Slough, GB 14 149
Mansell, Howard Langham Burnham, GB 23 133

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